|
KMID : 1134820080370040437
|
|
Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 4 p.437 ~ p.444
|
|
|
Effect of Ginseng and Herbal Plant Mixtures on Anti-Obesity in Obese SD Rat Induced by High Fat Diet
|
|
Lee Seong-Kye
So Seung-Ho
Hwang Eui-Il
Koo Bon-Suk
Han Gyeong-Ho
Ko Sang-Beom
Kim Na-Mi
|
|
|
Abstract
|
|
|
Anti-obesity effects of ginseng and herbal plant mixtures were investigated to develop natural materials
for anti-obesity. After inducing obesity with high fat diet for 8 weeks in male SD rats, ginseng and herbal
plant mixtures DM1 (ginseng, puer tea, opuntia) and DM2 (ginseng, puer tea) were administrated orally to
rats for another 8 weeks. During administration, food efficacy ratio and body weight of rat were measured
twice weekly. After administration, body weight, body fat contents, and serum lipid level were estimated for
anti-obesity effect and hematological analysis blood level of ALP and ASP was checked for safety. Body weight
in rats fed high fat diet was significantly increased. Body weight in obese rats induced by high fat diet was
significantly decreased by DM1 and DM2 feedings. The amount of body fat (epididymal, perirenal and visceral
fat, brown adipose tissue) was significantly reduced by DM1 and DM2 treatments. The amount of TG, the
concentration of leptin in blood plasma, and the concentration of insulin in blood plasma were significantly
diminished by DM1 and DM2. Lipid accumulation on liver was reduced in DM2. There were no side effects
among all groups according to blood analysis, hematological findings, and body weight. The findings of this
study suggest that DM1 and DM2 may be effective materials for anti-obesity through reducing plasma
triglyceride and body fats, and also decreasing body weight without side effects.
|
|
|
KEYWORD
|
|
|
ginseng, puer tea, opuntia, anti-obesity, body weight
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|